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Search Results for " pc 9 "

Targets Recommended: Apoptosis EGFR

8

抑制剂 & 化合物

18

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T16996	TAS6417	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	TAS6417 是一种高效的、具有口服活性的 EGFR 突变型抑制剂，可独特的结合到 EGFR 铰链区的 ATP 结合位点，其 IC50值为 1.1-8.0 nM。
T2490	Osimertinib AZD-9291,Mereletinib,奥希替尼	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib (AZD-9291) 是一种 EGFR 三代抑制剂，抑制二代 EGFR 抑制剂产生的 T790M 耐药突变，具有不可逆性和口服活性。Osimertinib 具有抗肿瘤活性，用于治疗 EGFR 突变的非小细胞肺癌。
T3634	Osimertinib mesylate 甲磺酸奥希替尼,Mereletinib mesylate,奥希替尼甲磺酸盐,AZD-9291 mesylate	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Osimertinib mesylate (Mereletinib mesylate) 是一种不可逆的突变选择性 EGFR 抑制剂，对EGFRL858R 和EGFRL858R/T790M 的IC50值分别为 12 和 1 nM。
T15044	D609	Apoptosis; Antioxidant	Apoptosis; oxidation-reduction
	D609 (Tricyclodecan-9-yl-Xanthogenate) 具有广泛的生物活性，包括抗氧化、抗凋亡、抗胆碱能、抗肿瘤、抗炎、抗病毒、抗增殖和神经保护活性。D609 通过引起磷脂酰胆碱 (PC) 特异性磷脂酶 C (PC-PLC) 和鞘磷脂合酶 (SMS) 的竞争性抑制来发挥作用。
T61935	B-Raf IN 9
	B-Raf IN 9 (compound 8b) 是有效的B-Raf 抑制剂（IC50= 24.79 nM）。B-Raf IN 9 将细胞周期阻滞于 G2/M 期，诱导凋亡。B-Raf IN 9 对人前列腺癌 PC-3 细胞表现出较强的抗肿瘤活性（IC50= 7.83 μM）。
T79152	PROTAC EGFR degrader 8	EGFR	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	PROTACEGFRdegrader 8 (T-184) 是一种能够定向降解EGFR的PROTACEGFR降解剂，其在HCC827细胞中的DC50为15.56 nM。该化合物有效抑制多种肺癌细胞系，包括H1975、PC-9和HCC827，其IC50分别为7.72 nM、121.9 nM和14.21 nM。PROTACEGFRdegrader 8 主要用于研究非小细胞肺癌（NSCLC）。
T37585	Ensartinib
	Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or point mutations is tested. Ensartinib is potent in H3122 lung cancer cells harboring EML4-ALK E13;A20 (IC50: 15nM). Ensartinib is also potent in H2228 lung cancer cells harboring EML4-ALK E6a/b; A20 (IC50: 45 nM). Furthermore, X-376 is potent in SUDHL-1 lymphoma cells harboring N...
T35897	ASK120067
	ASK120067 is a potent and orally active inhibitor of EGFRT790M (IC50:0.3 nM) with selectivity over EGFRWT (IC50:6.0 nM). ASK120067 is a third-generation EGFR-TKI for the research of non-small cell lung cancer (NSCLC)[1]. In the in vitro kinase assay ASK120067 potently inhibits the EGFR L858R/T790M and EGFR T790M resistant mutants with IC50 values of 0.3 nM and 0.5 nM, respectively, as well as the EGFRexon19del sensitizing mutant (IC50= 0.5 nM). The 50 of ASK120067 against wild-type EGFR (EGFRWT...

化合物

Cat.No: T16996

Target: Apoptosis, EGFR

Cat.No: T2490

Synonym: AZD-9291,Mereletinib,奥希替尼

Target: EGFR

Osimertinib mesylate

Cat.No: T3634

Synonym: 甲磺酸奥希替尼,Mereletinib mesylate,奥希替尼甲磺酸盐,AZD-9291 mesylate

Target: EGFR

Cat.No: T15044

Target: Apoptosis, Antioxidant

Cat.No: T61935

PROTAC EGFR degrader 8

Cat.No: T79152

Target: EGFR

Cat.No: T37585

Cat.No: T35897

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05131	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated NARC-1,PC9,LDLCQ1,NARC1,FH3,proprotein con...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with His and Avi tag. The predicted molecular weight is 74.3 kDa and the accession number is Q8NBP7-1.
TMPY-00408	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) FH3,proprotein convertase subtilisin/kexin type 9,L...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is AAV67948.1.
TMPY-04966	PCSK9 Protein, Human, Recombinant (D374Y, His) LDLCQ1,NARC-1,PC9,NARC1,HCHOLA3,proprotein...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.5 kDa and the accession number is Q8NBP7-1.
TMPJ-00443	PCSK9 Protein, Macaca nemestrina, Recombinant (His) Proprotein Convertase Subtilisin/Kexin Type 9,P...	Macaca nemestrina	HEK293 Cells
	Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) is a secretory subtilase belonging to the proteinase K subfamily. PCSK9 is synthesized as a soluble zymogen that undergoes autocatalytic intramolecular processing in the ER , the pro domain and mature chain secrete together through noncovalent interactions. PCSK9 binds with low-density lipoprotein receptor (LDLR) and plays a major regulatory role in cholesterol homeostasis. PCSK9 also plays a role in the neural development.
TMPY-05199	PCSK9 Protein, Human, Recombinant (D374Y, mFc) PC9,proprotein convertase subtilisin/kexin...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05218	PCSK9 Protein, Human, Recombinant (mFc) HCHOLA3,PC9,proprotein convertase subtilis...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.4 kDa and the accession number is Q8NBP7-1.
TMPJ-00369	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC<...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-8xHis-HA-Avi tag. The predicted molecular weight is 18 and 58-70 and 90-150 KDa and the accession number is Q8NBP7.
TMPY-05217	PCSK9 Protein, Mouse, Recombinant (mFc) HCHOLA3,Narc1,AI415265,AI747682,FH3,proprotein convertase su...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.6 kDa and the accession number is Q80W65.
TMPY-01245	PCSK9 Protein, Mouse, Recombinant (His) proprotein convertase subtilisin/kexin type 9,AI747...	Mouse	HEK293 Cells
	PCSK9 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q80W65.
TMPY-05270	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated FH3,NARC-1,PC9,LDLCQ1,proprotein convertas...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 97.5 kDa and the accession number is Q8NBP7-1.
TMPY-05114	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated LDLCQ1,NARC-1,PC9,FH3,NARC1,HCHOLA3,propro...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 72.6 kDa and the accession number is Q8NBP7-1.
TMPJ-00368	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated Subtilisin/Kexin-Like Protease PC9,PC<...	Human	HEK293 Cells
	PCSK9 Protein, Human, Recombinant (Avi), Biotinylated is expressed in HEK293 mammalian cells with C-Avi tag. The predicted molecular weight is 19&65 KDa and the accession number is Q8NBP7.
TMPJ-00865	VEGF121 Protein, Human, Recombinant (His) VEGFA,VEGF-A,Vascular permeability factor,VPF,血管内皮生长因子,Vascu...	Human	HEK293 Cells
	Human VEGF121, also known as Vascular endothelial growth factor A, VEGFA, Vascular permeability factor, VPF and VEGF, is a homodimeric, heparin-binding glycoprotein which belongs to the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family. VEGF-A is a glycosylated mitogen that specifically acts on endothelial cells and has various effects, including mediating increased vascular permeability, inducing angiogenesis, vasculogenesis, permeabilization of blood vessel...
TMPY-03698	VEGF121b Protein, Human, Recombinant MVCD1,VEGF,VPF,vascular endothelial growth factor A	Human	HEK293 Cells
	VEGF121b Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 34.10 kDa and the accession number is P15692-9.
TMPH-00005	YAP1 Protein, Human, Recombinant (Isoform 9, His) YAP1-2delta	Human	P. pastoris (Yeast)
	YAP1 Protein, Human, Recombinant (Isoform 9, His) is expressed in yeast with C-6xHis tag. The predicted molecular weight is 56.4 kDa; 80 kDa, reducing conditions and the accession number is P46937-9.
TMPK-00825	VEGF121 Protein, Human, Recombinant (His & Avi) VPF,VEGF,VEGFA,VEGFMGC70609,血管内皮生长因子,MGC70609	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPK-00826	VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated VAS,VEGFMGC70609,RP1-261G23.1,血管内皮生长因子,VEGFA,VPF,MV...	Human	HEK293 Cells
	Vascular endothelial growth factor (VEGF or VEGF-A), also known as vascular permeability factor (VPF), is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189. VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17 kDa and the accession number is P15692-9.
TMPY-05268	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated NRCAML,neurofascin,NF	Human	HEK293 Cells
	Neurofascin Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 130 kDa and the accession number is O94856-9.

重组蛋白

PCSK9 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPY-05131

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His)

Cat.No: TMPY-00408

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, His)

Cat.No: TMPY-04966

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Macaca nemestrina, Recombinant (His)

Cat.No: TMPJ-00443

Species: Macaca nemestrina

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc)

Cat.No: TMPY-05199

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (mFc)

Cat.No: TMPY-05218

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (His & HA & Avi), Biotinylated

Cat.No: TMPJ-00369

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (mFc)

Cat.No: TMPY-05217

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01245

Species: Mouse

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y, mFc), Biotinylated

Cat.No: TMPY-05270

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (D374Y & V474I & G670E, His), Biotinylated

Cat.No: TMPY-05114

Species: Human

Expression System: HEK293 Cells

PCSK9 Protein, Human, Recombinant (Avi), Biotinylated

Cat.No: TMPJ-00368

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00865

Species: Human

Expression System: HEK293 Cells

VEGF121b Protein, Human, Recombinant

Cat.No: TMPY-03698

Species: Human

Expression System: HEK293 Cells

YAP1 Protein, Human, Recombinant (Isoform 9, His)

Cat.No: TMPH-00005

Species: Human

Expression System: P. pastoris (Yeast)

VEGF121 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00825

Species: Human

Expression System: HEK293 Cells

VEGF121 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00826

Species: Human

Expression System: HEK293 Cells

Neurofascin Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05268

Species: Human

Expression System: HEK293 Cells

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